Selected Publications
“Progress Toward a Semi-Synthetic Organism with an Unrestricted Expanded Genetic Alphabet”, Dien, V. T. Holcomb, M., Feldman, A. W., Fishers, E. C., Dwyer, T. J., Romesberg, F. R., J. Am. Chem. Soc., 140 (47), 16115–16123 (2018).
“KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry”, Betz, K.; Malyshev, D. A.; Lavergne, T.; Welte, W.; Diederichs, K.; Dwyer, T.J.; Ordoukhanian, P.; Romesberg, F.E.; Marx, A., Nature Chemical Biology, 8, 612–614 (2012).
“Enabling Bifunctionality and Hemilability of N-Heteroaryl NHC Complexes”, Specht, Z.; Cortes-Llamas, S.; Tran, H.; van Niekerk, C.; Rancudo, K.; Golen, J.; Moore, C.; Rheingold, A.; Dwyer, T.J.; Grotjahn, D., Chemistry – A European Journal, 17, 6606-6609 (2011).
“NMR Solution Structure of a DNA-Actinomycin D Complex Containing a Non-Hydrogen Bonding Pair in the Binding Site”, Cravens, S.L,*; Navapanich, A.C.*; Geierstanger, B. H.; Tahmassebi, D.C.; Dwyer, T. J., J. Am. Chem. Soc., 132, 17588-17598 (2010).
"Solution Structure of a DNA Duplex Containing a Guanine-Difluorotluene Pair: A Wobble Pair Without Hydrogen Bonding?" Pfaff, D.A.; Clarke, K.M.; Parr, T.A.; Cole, J.M.; Geierstanger, B.H.; Tahmassebi, D.C.; Dwyer, T.J., J. Am. Chem. Soc. 130 (14), 4869-4878 (2008).
"Efforts toward Expansion of the Genetic Alphabet: Structure and Replication of Unnatural Base Pairs", Matsuda, S.; Fillo, J. D.; Henry, A. A.; Rai, P.; Wilkens, S. J.; Dwyer, T. J.; Geierstanger, B. H.; Wemmer, D. E.; Schultz, P. G.; Spraggon, G.; Romesberg, F. E., J. Am. Chem. Soc., 129(34), 10466-10473 (2007).
"Assaying a-Dicarbonyl Compounds in Wine using a Complementary GC-MS, HPLC and Visible Spectrophotometric Analysis", Dwyer, T. J.; Fillo, J. D., J. Chem. Ed. 83(2), 273-276 (2006).
"A High-Resolution NMR Solution Structure of a Cyclic Polyamide:DNA Complex Determined by Molecular Dynamics and Simulated Annealing", Chang, C. C.; Dwyer, T. J.; Tsui, V.; Case, D. A.; Dervan, P. B.; Wemmer, D. E., J. Am. Chem. Soc. 25, 7958-7966 (2004).
"N-Alkenyl Amide Rotational Barriers by 2D EXSY NMR", Aguirre, G.; Somanathan, R.; Hellberg, L. H.; Dwyer, T. J.; North, R., Magn. Reson. Chem. 41, 131 (2003).
"Protonation of beta-Cyanoenamines: NMR Spectroscopic and Calculational Studies of Ketenimine Amidinium Ion Formation", Dwyer, T. J.; Jasien, P. G.; Kirkowski, S.; Buxton, C. M.; Arruda, J. M.; Mitchell, G. W., J. Am. Chem. Soc., 120(49), 12942-12949 (1998).
"Rotational Barriers in Push-Pull Ethylenes: An Advanced Physical-Organic Project Including 2D EXSY and Computational Chemistry", Dwyer, T. J.; Norman, J. A.; Jasien, P. G., J. Chem. Ed., 75, 1635-1640 (1998).
"Electronic Effects in a Prototype Push-Pull Ethylene: A Study of the Rotational Barriers in C4H4N4 Isomers", Dwyer, T. J.; Jasien, P. G.; J. Mol. Struc. (Theochem), 363, 139 (1996).
"Solution Structures of Psoralen Monoadducted and Cross-Linked DNA Oligomers by NMR Spectroscopy and Restrained Molecular Dyanmics", Spielmann, H. P.; Dwyer, T. J.; Hearst, J. E.; Wemmer, D. E.; Biochemistry, 34, 12937 (1995).
"The Structure of U17 Isolated from Streptomyces Clavuligerus and its Properties as an Antioxidant Thiol", Newton, G. L.; Bewley, C. A.; Dwyer, T. J.; Horn, R.; Aharonowitz, Y.; Cohen, G.; Davies, J.; Faulkner, D. J.; Fahey, R. C.; Eur. J. Biochem., 230, 821 (1995).
"DNA Structual Reorganization upon Conversion of a Psoralen Furan-Side Monoadduct to an Interstrand Cross-link: Implications for DNA Repair", Spielmann, H. P.; Dwyer, T. J.; Sastry, S. S.; Hearst, J. E.; Wemmer, D. E.; Proc. Natl. Acad. Sci. USA, 92, 2345 (1995).
"Interaction of Minor Groove Ligands to an AAATT/AATTT Site: Correlation of Thermodynamic Characterization and Solution Structure", Rentzeperis, D.; Marky, L. A.; Dwyer, T. J.; Geierstanger, B. H.; Pelton, J. G.; Wemmer, D. E.; Biochemistry, 34, 2937 (1995).
"2D-EXSY Study of Proton Exchange in Aqueous Ammonium Ion: H/D Kinetic Isotope Effect for Direct Nitrogen-to-Nitrogen Proton Transfer", Perrin, C. L.; Dwyer, T. J.; Baine, P.; J. Am. Chem. Soc., 116, 4044 (1994).
"Minor Groove Recognition of DNA by Distamycin and its Analogs", Wemmer, D. E.; Geierstanger, B. H.; Fagan, P. A.; Dwyer, T. J.; Jacobsen, J. P.; et. al.; in Proceedings of the Eigth Conversation on Biomolecular Stereodynamics, R. H. Sarma and M. H. Sarma, Eds., Adenine Press, 301 (1994).
"Structural Analysis of Covalently-Linked Peptides in Complex with 5'-TGACT-3' Sites by Two-Dimensional NMR", Dwyer, T. J.; Geierstanger, B. H.; Mrksich, M.; Dervan, P. B.; Wemmer, D. E.; J. Am. Chem. Soc., 115, 9900 (1993).
"NMR Characterization of a Heterocomplex Formed Between Distamycin and its Analog 2-ImD with d(CGCAAGTTGGC)¥d(GCCAACTTGCG): Preference for the 1:1:1 2-ImD:Dst:DNA Complex over the 2:1 2-ImD:DNA and the 2:1 Dst:DNA Complex", Geierstanger, B. H.; Dwyer, T. J.; Bathini, Y., Lown, J. W.; Wemmer, D. E.; J. Am. Chem. Soc., 115, 4474 (1993).
"Determination of DNA Conformational Features by Selective Two-Dimensional NMR", Emsley, L.; Dwyer, T. J.; Spielmann, H. P.; Wemmer, D. E.; J. Am. Chem. Soc., 115, 7765 (1993).
"Antiparallel Side-By-Side Dimeric Motif for Sequence Specific Recognition in the Minor Groove of DNA by the Designed Peptide 1-Methylimidazole-2-carboxamide-netropsin", Mrksich, M.; Wade, W. S.; Dwyer, T. J.; Geierstanger, B. H.; Wemmer, D. E.; Dervan, P. B.; Proc. Natl. Acad. Sci. USA, 89, 7586 (1992).
"Design and Binding of a Distamycin A Analog to d(CGCAAGTTGGC)¥d(GCCAACTTGCC): Synthesis, NMR Studies and Implications for the Design of Sequence-Specfic Minor Groove Binding Oligopeptides", Dwyer, T. J.; Geierstanger, B. H.; Bathini, Y.; Lown, J. W.; Wemmer, D. E.; J. Am. Chem. Soc., 114, 5911 (1992).
"Application of Two-Dimensional NMR to Kinetics of Chemical Exchange", Perrin, C. L.; Dwyer, T. J.; Chem. Rev., 90(6), 935 (1990).
"Exchange of Amide Protons. Effect of Intramolecular Hydrogen Bonding", Perrin, C. L.; Dwyer, T. J.; Rebek, J., Jr.; Duff, R. J.; J. Am. Chem. Soc., 112, 3112 (1990).