Selected Publications

KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry”, Betz, K.; Malyshev, D. A.; Lavergne, T.; Welte, W.; Diederichs, K.; Dwyer, T.J.; Ordoukhanian, P.; Romesberg, F.E.; Marx, A., Nature Chemical Biology, 8, 612–614 (2012).

Enabling Bifunctionality and Hemilability of N-Heteroaryl NHC Complexes”, Specht, Z.; Cortes-Llamas, S.; Tran, H.; van Niekerk, C.; Rancudo, K.; Golen, J.; Moore, C.; Rheingold, A.; Dwyer, T.J.; Grotjahn, D., Chemistry – A European Journal, 17, 6606-6609 (2011).

NMR Solution Structure of a DNA-Actinomycin D Complex Containing a Non-Hydrogen Bonding Pair in the Binding Site”, Cravens, S.L,*; Navapanich, A.C.*; Geierstanger, B. H.; Tahmassebi, D.C.; Dwyer, T. J., J. Am. Chem. Soc., 132, 17588-17598 (2010).

"Solution Structure of a DNA Duplex Containing a Guanine-Difluorotluene Pair: A Wobble Pair Without Hydrogen Bonding?" Pfaff, D.A.; Clarke, K.M.; Parr, T.A.; Cole, J.M.; Geierstanger, B.H.; Tahmassebi, D.C.; Dwyer, T.J., J. Am. Chem. Soc. 130 (14), 4869-4878 (2008).

"Efforts toward Expansion of the Genetic Alphabet: Structure and Replication of Unnatural Base Pairs", Matsuda, S.; Fillo, J. D.; Henry, A. A.; Rai, P.; Wilkens, S. J.; Dwyer, T. J.; Geierstanger, B. H.; Wemmer, D. E.; Schultz, P. G.; Spraggon, G.; Romesberg, F. E., J. Am. Chem. Soc., 129(34), 10466-10473 (2007).

"Assaying a-Dicarbonyl Compounds in Wine using a Complementary GC-MS, HPLC and Visible Spectrophotometric Analysis", Dwyer, T. J.; Fillo, J. D., J. Chem. Ed. 83(2), 273-276 (2006).

"A High-Resolution NMR Solution Structure of a Cyclic Polyamide:DNA Complex Determined by Molecular Dynamics and Simulated Annealing", Chang, C. C.; Dwyer, T. J.; Tsui, V.; Case, D. A.; Dervan, P. B.; Wemmer, D. E., J. Am. Chem. Soc. 25, 7958-7966 (2004).

"N-Alkenyl Amide Rotational Barriers by 2D EXSY NMR", Aguirre, G.; Somanathan, R.; Hellberg, L. H.; Dwyer, T. J.; North, R., Magn. Reson. Chem. 41, 131 (2003).

"Protonation of beta-Cyanoenamines: NMR Spectroscopic and Calculational Studies of Ketenimine Amidinium Ion Formation", Dwyer, T. J.; Jasien, P. G.; Kirkowski, S.; Buxton, C. M.; Arruda, J. M.; Mitchell, G. W., J. Am. Chem. Soc., 120(49), 12942-12949 (1998).

"Rotational Barriers in Push-Pull Ethylenes: An Advanced Physical-Organic Project Including 2D EXSY and Computational Chemistry", Dwyer, T. J.; Norman, J. A.; Jasien, P. G., J. Chem. Ed., 75, 1635-1640 (1998).

"Electronic Effects in a Prototype Push-Pull Ethylene: A Study of the Rotational Barriers in C4H4N4 Isomers", Dwyer, T. J.; Jasien, P. G.; J. Mol. Struc. (Theochem), 363, 139 (1996).

"Solution Structures of Psoralen Monoadducted and Cross-Linked DNA Oligomers by NMR Spectroscopy and Restrained Molecular Dyanmics", Spielmann, H. P.; Dwyer, T. J.; Hearst, J. E.; Wemmer, D. E.; Biochemistry, 34, 12937 (1995).

"The Structure of U17 Isolated from Streptomyces Clavuligerus and its Properties as an Antioxidant Thiol", Newton, G. L.; Bewley, C. A.; Dwyer, T. J.; Horn, R.; Aharonowitz, Y.; Cohen, G.; Davies, J.; Faulkner, D. J.; Fahey, R. C.; Eur. J. Biochem., 230, 821 (1995).

"DNA Structual Reorganization upon Conversion of a Psoralen Furan-Side Monoadduct to an Interstrand Cross-link: Implications for DNA Repair", Spielmann, H. P.; Dwyer, T. J.; Sastry, S. S.; Hearst, J. E.; Wemmer, D. E.; Proc. Natl. Acad. Sci. USA, 92, 2345 (1995).

"Interaction of Minor Groove Ligands to an AAATT/AATTT Site: Correlation of Thermodynamic Characterization and Solution Structure", Rentzeperis, D.; Marky, L. A.; Dwyer, T. J.; Geierstanger, B. H.; Pelton, J. G.; Wemmer, D. E.; Biochemistry, 34, 2937 (1995).

"2D-EXSY Study of Proton Exchange in Aqueous Ammonium Ion: H/D Kinetic Isotope Effect for Direct Nitrogen-to-Nitrogen Proton Transfer", Perrin, C. L.; Dwyer, T. J.; Baine, P.; J. Am. Chem. Soc., 116, 4044 (1994).

"Minor Groove Recognition of DNA by Distamycin and its Analogs", Wemmer, D. E.; Geierstanger, B. H.; Fagan, P. A.; Dwyer, T. J.; Jacobsen, J. P.; et. al.; in Proceedings of the Eigth Conversation on Biomolecular Stereodynamics, R. H. Sarma and M. H. Sarma, Eds., Adenine Press, 301 (1994).

"Structural Analysis of Covalently-Linked Peptides in Complex with 5'-TGACT-3' Sites by Two-Dimensional NMR", Dwyer, T. J.; Geierstanger, B. H.; Mrksich, M.; Dervan, P. B.; Wemmer, D. E.; J. Am. Chem. Soc., 115, 9900 (1993).

"NMR Characterization of a Heterocomplex Formed Between Distamycin and its Analog 2-ImD with d(CGCAAGTTGGC)¥d(GCCAACTTGCG): Preference for the 1:1:1 2-ImD:Dst:DNA Complex over the 2:1 2-ImD:DNA and the 2:1 Dst:DNA Complex", Geierstanger, B. H.; Dwyer, T. J.; Bathini, Y., Lown, J. W.; Wemmer, D. E.; J. Am. Chem. Soc., 115, 4474 (1993).

"Determination of DNA Conformational Features by Selective Two-Dimensional NMR", Emsley, L.; Dwyer, T. J.; Spielmann, H. P.; Wemmer, D. E.; J. Am. Chem. Soc., 115, 7765 (1993).

"Antiparallel Side-By-Side Dimeric Motif for Sequence Specific Recognition in the Minor Groove of DNA by the Designed Peptide 1-Methylimidazole-2-carboxamide-netropsin", Mrksich, M.; Wade, W. S.; Dwyer, T. J.; Geierstanger, B. H.; Wemmer, D. E.; Dervan, P. B.; Proc. Natl. Acad. Sci. USA, 89, 7586 (1992).

"Design and Binding of a Distamycin A Analog to d(CGCAAGTTGGC)¥d(GCCAACTTGCC): Synthesis, NMR Studies and Implications for the Design of Sequence-Specfic Minor Groove Binding Oligopeptides", Dwyer, T. J.; Geierstanger, B. H.; Bathini, Y.; Lown, J. W.; Wemmer, D. E.; J. Am. Chem. Soc., 114, 5911 (1992).

"Application of Two-Dimensional NMR to Kinetics of Chemical Exchange", Perrin, C. L.; Dwyer, T. J.; Chem. Rev., 90(6), 935 (1990).

"Exchange of Amide Protons. Effect of Intramolecular Hydrogen Bonding", Perrin, C. L.; Dwyer, T. J.; Rebek, J., Jr.; Duff, R. J.; J. Am. Chem. Soc., 112, 3112 (1990).